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Pragmatic trials are those that are designed to inform the practice of clinical trials in real life. They are often described by their focus on practical aspects of designing a study that include the recruitment process and consent, adhering and the use of standard equipment.
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Pragmatic, a software company, offers a variety of casino games to online gambling platforms. Pragmatic's iGaming solutions are used by the most reputable operators as well as casinos with a physical location. The company offers front-end design tools, analysis tools, promotions, marketing payment systems, security, customer service and bug reporting. In addition, the company provides its players a secure environment that features high-quality graphics and games.
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RTP
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A pragmatic trial that uses a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is necessary for pragmatic trials to be valid and also helps to reduce the chance of bias in the results. However too much heterogeneity could cause issues with the design of the trial.
Pragmatic Play Pragmatic Play, a major player on the live casino market offers an array of traditional table games like Blackjack and Roulette. The company's live studios in Romania and Malta offer a real-life gambling experience for players, as well as a full suite of virtual betting options. The company also has created various interactive games to make gambling online enjoyable. Some of these shows are telecast live and some include famous people from the industry.
Mobile compatibility
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Pragmatic Play offers not only mobile-friendly slot machines, but also live casino and table games. The company is licensed by a variety of regulatory bodies, including Malta Gaming Authority and UK Gambling Commission. The company's games are secured with high-end encryption and its security team is on hand to assist players with any issues.
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Legality
Pragmatic Play is known for its top-notch games, and also for providing an outstanding user experience. Its software is designed to work on mobile devices and supports different languages. Despite its infancy it has already established itself as a leading gaming platform for casinos. The most recent releases include Wolves 5 reel video slot with a healthful RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.
The aim of pragmatic trials is to replicate real-life scenarios and gain the highest level of validity externally. Usually, they are commissioned by policymakers and practitioners to guide their decisions. They can also be a great method to determine the causal relationship between the intervention and its effects. However, they should not be used as a substitute for the use of explanation trials.
The pragmatism concept is controversial, and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm a physiological or clinical hypothesis and pragmatic trials, which inform policy and practice decisions. They also proposed a framework for pragmatic trials, which they called PRECIS.2 This tool was designed to define the elements of a pragmatic trial that include recruitment, design and delivery of the intervention, as well as follow-up.
The number of pragmatic trials is increasing. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs), yielded 34 articles, shown in red in Figure 2. This is a sign that the health sciences community is becoming more acquaint to the issue of pragmatism. However, it is important to remember that the majority of these studies were conducted in primary care settings.